A blog from the Centre for Research Ethics & Bioethics (CRB)

Tag: consciousness (Page 1 of 4)

The hard problem of consciousness: please handle with care!

We face challenges every day. Some are more demanding than others, but it seems that there is not a day without some problem to handle. Unless they are too big to manage, problems are like the engines of our lives. They push us to always go beyond wherever we are and whatever we do, to look for new possibilities, to build new opportunities. In other words: problems make us stay alive.

The same is true for science and philosophy. There is a constant need to face new challenges. Consciousness research is no exception. There are, of course, several problems in the investigation of consciousness. However, one problem has emerged as the big problem, which the Australian philosopher David Chalmers baptised “the hard problem of consciousness.” This classical problem (discussed even before Chalmers coined this expression, actually since the early days of neuropsychology, notably by Alexander Luria and collaborators) refers to the enigma of subjective experience. To adapt a formulation by the philosopher Thomas Nagel, the basic question is: why do we have experiences of what it is like to be conscious, for example, why do we experience that pain and hunger feel the way they do?

The hard problem has a double nature. On the one hand, it refers to what Joseph Levine had qualified as an explanatory gap. The strategy to identify psychological experiences with physical features of the brain is in the end unable to explain why experiences are related to physical phenomena at all. On the other hand, the hard problem also refers to the question if subjective experience can be explained causally or if it is intrinsic to the world, that is to say: fundamentally there, from the beginning, rather than caused by something more primary.

This double nature of the problem has been a stumbling block in the attempt to explain consciousness. Yet in recent years, the hardness of the problem has been increasingly questioned. Among the arguments that appear relevant in order to soften the problem, there is one that I think merits specific attention. This argument describes consciousness as a cultural concept, meaning that both the way we conceive it and the way we experience it depend on our culture. There are different versions of this argument: some reduce consciousness as such to a cultural construction, while other, less radical arguments stress that consciousness has a neurological substrate that is importantly shaped by culture. The relevant point is that by characterising consciousness as a cultural construction, with reference both to how we conceptualise it and how we are conscious, this argument ultimately questions the hardness of the hard problem.

To illustrate, consider anthropological and neuroscientific arguments that appear to go in the direction of explaining away the hard problem of consciousness. Anthropological explanations give a crucial role to culture and its relationship with consciousness. Humans have an arguably unique capacity of symbolisation, which enables us to create an immaterial world both through the symbolisation of the actual world and through the construction of immaterial realities that are not experienced through the senses. This human symbolic capacity can be applied not only to the external world, but also to brain activity, resulting in the conceptual construction of notions like consciousness. We symbolise our brain activity, hypostatise our conscious activities, and infer supposedly immaterial causes behind them.

There are also neuroscientific and neuropsychological attempts to explain how consciousness and our understanding of it evolved, which ultimately appear to potentially explain away the hard problem. Attention Schema Theory, for instance, assumes that people tend to “attribute a mysterious consciousness to themselves and to others because of an inherently inaccurate model of mind, and especially a model of attention.” The origin of the attribution of this mysterious consciousness is in culture and in folk-psychological beliefs, for instance, ideas about “an energy-like substance inhabiting the body.” In other words, culturally based mistaken beliefs derived from implicit social-cognitive models affect and eventually distort our view of consciousness. Ultimately, consciousness does not really exist as a distinct property, and its appearance as a non-physical property is a kind of illusion. Thus, the hard problem does not originate from real objective features of the world, but rather from implicit subjective beliefs derived from internalised socio-cultural models, specifically from the intuition that mind is an invisible essence generated within an agent.

While I do not want to conceptually challenge the arguments above, I here only suggest potential ethical issues that might arise if we assume the validity of those arguments. What are the potential neuroethical implications of these ideas of consciousness as culturally constructed? Since the concept of consciousness traditionally played an important role in ethical reasoning, for example, in the notion of a person, questioning the objective status of conscious experience may have important ethical implications that should be adequately investigated. For instance, if consciousness depends on culture, then any definition of altered states of consciousness is culturally relative and context-dependent. This might have an impact on, for example, the ethical evaluation of the use of psychotropic substances, which for some cultures, as history tells us, can be considered legitimate and positive. Why should we limit the range of states of consciousness that are allowed to be experienced? What makes it legitimate for a culture to assert its own behavioural standards? To what extent can individuals justify their behaviour by appealing to their culture? 

In addition, if consciousness (i.e., the way we are conscious, what we are conscious of, and our understanding of consciousness) is dependent on culture, then some conscious experiences might be considered more or less valuable in different cultural contexts, which could affect, for example, end-of-life decisions. If the concept of consciousness, and thus its ethical relevance and value, depends on culture, then consciousness no longer offers a solid foundation for ethical deliberation. Softening the hard problem of consciousness might also soften the foundation of what I defined elsewhere as the consciousness-centred ethics of disorders of consciousness (vegetative states, unresponsive wakefulness states, minimally conscious states, and cognitive-motor dissociation).

Although a cultural approach to consciousness can soften the hard problem conceptually, it creates hard ethical problems that require specific attention. It seems that any attempt to challenge the hard problem of consciousness results in a situation similar to that of having a blanket that is too short: if you pull it to one side (in the direction of the conceptual problem), you leave the other side uncovered (ethical issues based on the notion of consciousness). It seems that we cannot soften the hard problem of consciousness without the risk of relativizing ethics.

Written by…

Michele Farisco, Postdoc Researcher at Centre for Research Ethics & Bioethics, working in the EU Flagship Human Brain Project.

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Are you conscious? Looking for reliable indicators

How can we be sure that a person in front of us is conscious? This might seem like a naïve question, but it actually resulted in one of the trickiest and most intriguing philosophical problems, classically known as “the other minds problem.”

Yet this is more than just a philosophical game: reliable detection of conscious activity is among the main neuroscientific and technological enterprises today. Moreover, it is a problem that touches our daily lives. Think, for instance, of animals: we are (at least today) inclined to attribute a certain level of consciousness to animals, depending on the behavioural complexity they exhibit. Or think of Artificial Intelligence, which exhibits astonishing practical abilities, even superior to humans in some specific contexts.

Both examples above raise a fundamental question: can we rely on behaviour alone in order to attribute consciousness? Is that sufficient?

It is now clear that it is not. The case of patients with devastating neurological impairments, like disorders of consciousness (unresponsive wakefulness syndrome, minimally conscious state, and cognitive-motor dissociation) is highly illustrative. A number of these patients might retain residual conscious abilities although they are unable to show them behaviourally. In addition, subjects with locked-in syndrome have a fully conscious mind even if they do not exhibit any behaviours other than blinking.

We can conclude that absence of behavioural evidence for consciousness is not evidence for the absence of consciousness. If so, what other indicators can we rely on in order to attribute consciousness?

The identification of indicators of consciousness is necessarily a conceptual and an empirical task: we need a clear idea of what to look for in order to define appropriate empirical strategies. Accordingly, we (a group of two philosophers and one neuroscientist) conducted joint research eventually publishing a list of six indicators of consciousness.  These indicators do not rely only on behaviour, but can be assessed also through technological and clinical approaches:

  1. Goal directed behaviour (GDB) and model-based learning. In GDB I am driven by expected consequences of my action, and I know that my action is causal for obtaining a desirable outcome. Model-based learning depends on my ability to have an explicit model of myself and the world surrounding me.
  2. Brain anatomy and physiology. Since the consciousness of mammals depends on the integrity of particular cerebral systems (i.e., thalamocortical systems), it is reasonable to think that similar structures indicate the presence of consciousness.
  3. Psychometrics and meta-cognitive judgement. If I can detect and discriminate stimuli, and can make some meta-cognitive judgements about perceived stimuli, I am probably conscious.
  4. Episodic memory. If I can remember events (“what”) I experienced at a particular place (“where”) and time (“when”), I am probably conscious.
  5. Acting out one’s subjective, situational survey: illusion and multistable perception. If I am susceptible to illusions and perceptual ambiguity, I am probably conscious.
  6. Acting out one’s subjective, situational survey: visuospatial behaviour. Our last proposed indicator of consciousness is the ability to perceive objects as stably positioned, even when I move in my environment and scan it with my eyes.

This list is conceived to be provisional and heuristic but also operational: it is not a definitive answer to the problem, but it is sufficiently concrete to help identify consciousness in others.

The second step in our task is to explore the clinical relevance of the indicators and their ethical implications. For this reason, we selected disorders of consciousness as a case study. We are now working together with cognitive and clinical neuroscientists, as well as computer scientists and modellers, in order to explore the potential of the indicators to quantify to what extent consciousness is present in affected patients, and eventually improve diagnostic and prognostic accuracy. The results of this research will be published in what the Human Brain Project Simulation Platform defines as a “live paper,” which is an interactive paper that allows readers to download, visualize or simulate the presented results.

Written by…

Michele Farisco, Postdoc Researcher at Centre for Research Ethics & Bioethics, working in the EU Flagship Human Brain Project.

Pennartz CMA, Farisco M and Evers K (2019) Indicators and Criteria of Consciousness in Animals and Intelligent Machines: An Inside-Out Approach. Front. Syst. Neurosci. 13:25. doi: 10.3389/fnsys.2019.00025

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Anthropomorphism in AI can limit scientific and technological development

Anthropomorphism almost seems inscribed in research on artificial intelligence (AI). Ever since the beginning of the field, machines have been portrayed in terms that normally describe human abilities, such as understanding and learning. The emphasis is on similarities between humans and machines, while differences are downplayed. Like when it is claimed that machines can perform the same psychological tasks that humans perform, such as making decisions and solving problems, with the supposedly insignificant difference that machines do it “automated.”

You can read more about this in an enlightening discussion of anthropomorphism in and around AI, written by Arleen Salles, Kathinka Evers and Michele Farisco, all at CRB and the Human Brain Project. The article is published in AJOB Neuroscience.

The article draws particular attention to so-called brain-inspired AI research, where technology development draws inspiration from what we know about the functioning of the brain. Here, close relationships are emphasized between AI and neuroscience: bonds that are considered to be decisive for developments in both fields of research. Neuroscience needs inspiration from AI research it is claimed, just as AI research needs inspiration from brain research.

The article warns that this idea of ​​a close relationship between the two fields presupposes an anthropomorphic interpretation of AI. In fact, brain-inspired AI multiplies the conceptual double exposures by projecting not only psychological but also neuroscientific concepts onto machines. AI researchers talk about artificial neurons, synapses and neural networks in computers, as if they incorporated artificial brain tissue into the machines.

An overlooked risk of anthropomorphism in AI, according to the authors, is that it can conceal essential characteristics of the technology that make it fundamentally different from human intelligence. In fact, anthropomorphism risks limiting scientific and technological development in AI, since it binds AI to the human brain as privileged source of inspiration. Anthropomorphism can also entice brain research to uncritically use AI as a model for how the brain works.

Of course, the authors do not deny that AI and neuroscience mutually support each other and should cooperate. However, in order for cooperation to work well, and not limit scientific and technological development, philosophical thinking is also needed. We need to clarify conceptual differences between humans and machines, brains and computers. We need to free ourselves from the tendency to exaggerate similarities, which can be more verbal than real. We also need to pay attention to deep-rooted differences between humans and machines, and learn from the differences.

Anthropomorphism in AI risks encouraging irresponsible research communication, the authors further write. This is because exaggerated hopes (hype) seem intrinsic to the anthropomorphic language. By talking about computers in psychological and neurological terms, it sounds as if these machines already essentially functioned as human brains. The authors speak of an anthropomorphic hype around neural network algorithms.

Philosophy can thus also contribute to responsible research communication about artificial intelligence. Such communication draws attention to exaggerated claims and hopes inscribed in the anthropomorphic language of the field. It counteracts the tendency to exaggerate similarities between humans and machines, which rarely go as deep as the projected words make it sound.

In short, differences can be as important and instructive as similarities. Not only in philosophy, but also in science, technology and responsible research communication.

Pär Segerdahl

Written by…

Pär Segerdahl, Associate Professor at the Centre for Research Ethics & Bioethics and editor of the Ethics Blog.

Arleen Salles, Kathinka Evers & Michele Farisco (2020) Anthropomorphism in AI, AJOB Neuroscience, 11:2, 88-95, DOI: 10.1080/21507740.2020.1740350

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Artificial intelligence and living consciousness

The Ethics Blog will publish several posts on artificial intelligence in the future. Today, I just want to make a little observation of something remarkable.

The last century was marked by fear of human consciousness. Our mind seemed as mystic as the soul, as superfluous in a scientific age as God. In psychology, behaviorism flourished, which defined psychological words in terms of bodily behavior that could be studied scientifically in the laboratory. Our living consciousness was treated as a relic from bygone superstitious ages.

What is so remarkable about artificial intelligence? Suddenly, one seems to idolize consciousness. One wallows in previously sinful psychological words, at least when one talks about what computers and robots can do. These machines can see and hear; they can think and speak. They can even learn by themselves.

Does this mean that the fear of consciousness has ceased? Hardly, because when artificial intelligence employs psychological words such as seeing and hearing, thinking and understanding, the words cease to be psychological. The idea of computer “learning,” for example, is a technical term that computer experts define in their laboratories.

When artificial intelligence embellishes machines with psychological words, then, one repeats how behaviorism defined mind in terms of something else. Psychological words take on new machine meanings that overshadow the meanings the words have among living human beings.

Remember this next time you wonder if robots might become conscious. The development exhibits fear of consciousness. Therefore, what you are wondering is not if robots can become conscious. You wonder if your own consciousness can be superstition. Remarkable, right?

Pär Segerdahl

Written by…

Pär Segerdahl, Associate Professor at the Centre for Research Ethics & Bioethics and editor of the Ethics Blog.

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Neuroethics as foundational

As neuroscience expands, the need for ethical reflection also expands. A new field has emerged, neuroethics, which celebrated its 15th anniversary last year. This was noted in the journal AJOB Neuroscience through an article about the area’s current and future challenges.

In one of the published comments, three researchers from the Human Brain Project and CRB emphasize the importance of basic conceptual analysis in neuroethics. The new field of neuroethics is more than just a kind of ethical mediator between neuroscience and society. Neuroethics can and should contribute to the conceptual self-understanding of neuroscience, according to Arleen Salles, Kathinka Evers and Michele Farisco. Without such self-understanding, the ethical challenges become unclear, sometimes even imaginary.

Foundational conceptual analysis can sound stiff. However, if I understand the authors, it is just the opposite. Conceptual analysis is needed to make concepts agile, when habitual thinking made them stiff. One example is the habitual thinking that facts about the brain can be connected with moral concepts, so that, for example, brain research can explain to us what it “really” means to be morally responsible for our actions. Such habitual thinking about the role of the brain in human life may suggest purely imaginary ethical concerns about the expansion of neuroscience.

Another example the authors give is the external perspective on consciousness in neuroscience. Neuroscience does not approach consciousness from a first-person perspective, but from a third-person perspective. Neuroscience may need to be reminded of this and similar conceptual limitations, to better understand the models that one develops of the brain and human consciousness, and the conclusions that can be drawn from the models.

Conceptual neuroethics is needed to free concepts from intellectual deadlocks arising with the expansion of neuroscience. Thus, neuroethics can contribute to deepening the self-understanding of neuroscience as a science with both theoretical and practical dimensions. At least that is how I understand the spirit of the authors’ comment in AJOB Neuroscience.

Pär Segerdahl

Written by…

Pär Segerdahl, Associate Professor at the Centre for Research Ethics & Bioethics and editor of the Ethics Blog.

Emerging Issues Task Force, International Neuroethics Society (2019) Neuroethics at 15: The Current and Future Environment for Neuroethics, AJOB Neuroscience, 10:3, 104-110, DOI: 10.1080/21507740.2019.1632958

Arleen Salles, Kathinka Evers & Michele Farisco (2019) The Need for a Conceptual Expansion of Neuroethics, AJOB Neuroscience, 10:3, 126-128, DOI: 10.1080/21507740.2019.1632972

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An extended concept of consciousness and an ethics of the whole brain

Pär SegerdahlWhen we visit a newly operated patient, we probably wonder: Has she regained consciousness? The question is important to us. If the answer is yes then she is among us, we can socialize. If the answer is negative then she is absent, it is not possible to socialize. We can only wait and hope that she returns to us.

Michele Farisco at CRB proposes in a new dissertation a more extensive concept of consciousness. According to this concept, we are conscious without interruption, basically, as long as the brain lives. This sounds controversial. It appears insensitive to the enormous importance it has for us in everyday life whether someone is conscious or not.

Maybe I should explain right away that it is not about changing our usual ways of speaking of consciousness. Rather, Michele Farisco suggests a new neuroscientific concept of consciousness. Science sometimes needs to use familiar words in unfamiliar ways. For example, biology cannot speak of humans and animals as an opposition, as we usually do. For biology, the human is one of the animals. Just as biology extends the concept of an animal to us humans, Michele Farisco extends the concept of consciousness to the entire living brain.

Why can an extended concept of consciousness be reasonable in neuroscience? A simple answer is that the brain continues to be active, even when in the ordinary sense we lose consciousness and the ability to socialize. The brain continues to interact with the signals from the body and from the environment. Neural processes that keep us alive continue, albeit in modified forms. The seemingly lifeless body in the hospital bed is a poor picture of the unconscious brain. It may be very active. In fact, some types of brain processes are extra prominent at rest, when the brain does not respond to external stimuli.

Additional factors support an extended neuroscientific concept of consciousness. One is that even when we are conscious in the usual sense, many brain processes happen unconsciously. These processes often do the same work that conscious processes do, or support conscious processes, or are shaped by conscious processes. When we look neuroscientifically at the brain, our black and white opposition between conscious and unconscious becomes difficult to discern. It may be more reasonable to speak of continuities, of levels of the same consciousness, which always is inherent in the living brain.

In short, neuroscience may gain from not adopting our ordinary concept of consciousness, which makes such an opposition between conscious and unconscious. The difference that is absolute when we visit a newly operated patient – is she conscious or not? – is not as black and white when we study the brain.

Does Michele Farisco propose that neuroscience should make no difference whatsoever between what we commonly call conscious and unconscious, between being present and absent? No, of course not. Neuroscience must continue to explore that difference. However, we can understand the difference as a modification of the same basic consciousness, of the same basic brain activity. Neuroscience needs to study differences without falling victim to a black and white opposition. Much like biology needs to study differences between humans and other animals, even when it extends the concept of an animal to the human.

The point, then, is that neuroscience needs to be open to both difference and continuity. Michele Farisco proposes a neuroscientific distinction between aware and unaware consciousness. It captures both aspects, the difference and the continuity.

Michele Farisco’s extended concept of consciousness also has ethical consequences. It can motivate an ethics of the whole brain, not just of the conscious brain, in the usual sense. The question is no longer, merely, whether the patient is conscious or not. The question is at what level the patient is conscious. We may need to consider ethically even unconscious brains and brain processes, in the ordinary sense. For example, by talking calmly near the patient, even though she does not seem to hear, or by playing music that the patient usually appreciates.

Perhaps we should not settle for waiting and hoping that the patient will return to us. The brain is already here. At several levels, this brain may continue to socialize, even though the patient does not seem to respond.

If you want to know more about Michele Farisco’s extended concept of consciousness and his ethics of the whole brain, read the dissertation that he recently defended. You can also read about new technological opportunities to communicate with patients suffering from severe disorders of consciousness, and about new opportunities to diagnose such disorders.

Pär Segerdahl

Farisco, Michele. 2019. Brain, consciousness and disorders of consciousness at the intersection of neuroscience and philosophy. (Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1597.) Uppsala: Acta Universitatis Upsaliensis.

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Neuroethical reflection in the Human Brain Project

Arleen SallesThe emergence of several national level brain initiatives and the priority given to neuroscientific research make it important to examine the values underpinning the research, and to address the ethical, social, legal, philosophical, and regulatory issues that it raises.

Neuroscientific insights allow us to understand more about the human brain: about its dynamic nature and about its disorders. These insights also provide the basis for potentially manipulating the brain through neurotechnology and pharmacotherapy. Research in neuroscience thus raises multiple concerns: From questions about the ethical significance of natural and engineered neural circuitry, to the issue of how a biological model or a neuroscientific account of brain disease might impact individuals, communities, and societies at large. From how to protect human brain data to how to determine and guard against possible misuses of neuroscientific findings.

Furthermore, the development and applications of neuro-technology to alleviate symptoms or even enhance the human brain raise further concerns, such as their potential impact on the personality, agency, and autonomy of some users. Indeed, some empirical findings appear to even challenge long held conceptions about who we are, the capacity to choose freely, consciousness, and moral responsibility.

Neuroethics is the field of study devoted to examining these critical issues. Unfortunately, it has sometimes been reduced to a subfield of applied ethics understood as a merely procedural approach. However, in our understanding, neuroethics is methodologically much richer. It is concerned not just with using ethical theory to address normative issues about right and wrong, but notably with providing needed conceptual clarification of the relevant neuroscientific and philosophical notions. Only by having conceptual clarity about the challenges presented will we be able to address and adequately manage them.

So understood, neuroethics plays a key role in the Human Brain Project (HBP). The HBP is a European Community Flagship Project of Information and Computing Technologies (ICT). It proposes that to achieve a fuller understanding of the brain, it is necessary to integrate the massive volumes of both already available data and new data coming from labs around the world. Expected outcomes include the creation and operation of an ICT infrastructure for neuroscience and brain related research in medicine and computing. The goal is to achieve a multilevel understanding of the brain (from genes to cognition), its diseases and the effects of drugs (allowing early diagnoses and personalised treatments), and to capture the brain’s computational capabilities.

The HBP is funded by the European Commission in the framework of the EU’s Horizon 2020 research-funding programme. The programme promotes responsible research and innovation (RRI). RRI is generally understood as an interactive process that engages social actors, researchers, and innovators who must be mutually responsive and work towards the ethical permissibility of the relevant research and its products. The goal is to ensure that scientific progress and innovation are responsible and sustainable: that they increase individual and societal flourishing and maximize the common good.

To develop, broaden, and enhance RRI within the project, the HBP established the Ethics and Society subproject. Ethics and Society  is structured around a number of RRI activities such as foresight analysis (to identify at an early stage ethical and social concerns), citizens’ engagement (to promote involvement with different points of view and to strengthen public dialogue), and ethics support (to carry out research in applied ethics and to develop principles and mechanisms that ensure that ethical issues raised by research subprojects are communicated and managed and that HBP researchers comply with ethical codes and legal norms).

Neuroethical reflection plays a key role in this integration of social, scientific, and ethical inquiry. Notably, in the HBP such reflection includes conceptual and philosophical analysis. Insofar as it does, neuroethics aims to offer more than assistance to neuroscientists and social scientists in identifying the social, political, and cultural components of the research. Via conceptual analysis, neuroethics attempts to open a productive space within the HBP for examining the relevant issues, carrying out self-critical analysis, and providing the necessary background to examine potential impacts and issues raised. Neuroethical reflection in the HBP does not exclusively focus on ethical applications and normative guidance. Rather, it takes as a starting point the view that the full range of issues raised by neuroscience cannot be adequately dealt with without also focusing on the construction of knowledge, the meaning of the relevant notions, and the legitimacy of the various interpretations of relevant scientific findings.

At present, the importance of neuroethics is not in question. It is a key concern of the International Brain Initiative, and the different international brain projects are trying to integrate neuroethics into their research in different ways. What continues to be unique to neuroethics in the HBP, however, is its commitment to the idea that making progress in addressing the host of ethical, social, legal, regulatory and philosophical issues raised by brain research to a great extent depends on a conceptual neuroethical approach. It enables constructive critical alertness and a thought-out methodology that can achieve both substantial scientific ground and conceptual clarity.

If you want to read more, see below a list of publications on which this post is based.

Arleen Salles

Delegates eaGNS. Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives. Neuron. 2018.

Evers K, Salles A, Farisco M. Theoretical Framing for Neuroethics: The Need for a Conceptual Aproach. In: Racine E, Aspler, J., editor. Debates About Neuroethics: Springer; 2017.

Salles A, Evers K. Social Neuroscience and Neuroethics: A Fruitful Synergy. In: Ibanez A, Sedeno, L., Garcia, A., editor. Social Neuroscience and Social Science: The Missing Link: Springer; 2017. p. 531-46.

Farisco M, Salles A, Evers K. Neuroethics: A Conceptual Approach. Camb Q Healthc Ethics. 2018;27(4):717-27.

Salles A, Evers K, Farisco M. Neuroethics and Philosophy in Responsible Research and Innovation: The Case of the Human Brain Project. Neuroethics. 2018.

Salles A, Bjaalie JG, Evers K, Farisco M, Fothergill BT, Guerrero M, et al. The Human Brain Project: Responsible Brain Research for the Benefit of Society. Neuron. 2019;101(3):380-4.

Drug addiction as a mental and social disorder

Michele FariscoCan the brain sciences help us to better understand and handle urgent social problems like drug addiction? Can they even help us understand how social disorder creates disorderly, addicted brains?

If, as seems to be the case, addiction has a strong cerebral base, then it follows that knowing the brain is the key to finding effective treatments for addiction. Yet, what aspects of the brain should be particularly investigated? In a recent article, co-authored with the philosopher Kathinka Evers and the neuroscientist Jean-Pierre Changeux, I suggest that we need to focus on both aware and unaware processes in the brain, trying to figure out how these are affected by environmental influences, and how they eventually affect individual behavior.

There is no doubt that drug addiction is one of the most urgent emergencies in contemporary society. Think, for instance, of the opioid crisis in the US. It has become a kind of social plague, affecting millions of people. How was that possible? What are the causes of such a disaster? Of course, several factors contributed to the present crisis. We suggest, however, that certain external factors influenced brain processes on an unaware level, inviting addictive behavior.

To give an example, one of the causes of the opioid crisis seems to be the false assumption that opioid drugs do not cause addiction. Taking this view of opioid drugs was an unfortunate choice, we argue, likely favored by the financial interests of pharmaceutical companies. It affected not only physicians’ aware opinions, but also their unaware views on opioid drugs, and eventually their inclination to prescribe them. But that is not all. Since there is a general disposition to trust medical doctors’ opinions and choices, the original false assumption that opioid drugs do not cause addiction spread and affected also public opinion, especially at the unaware level. In other words, we think that there is a social responsibility for the increase in drug addiction, if not in ethical terms, at least in terms of public policies.

This is just an example of how external factors contribute to a personal disposition to use potentially addictive drugs. Of course, the factors involved in creating addiction are multifarious and not limited to false views about the risk of addiction associated with certain drugs.

More generally, we argue that in addition to the internal bases of addiction in the central nervous system, socio-economic status modulates, through unaware processing, what can be described as a person’s subjective “global well-being,” raising in some individuals the need for additional rewards in the brain. In the light of the impact of external factors, we argue that some people are particularly vulnerable to the pressures of the political and socio-economical capitalistic system, and that this stressful condition, which has both aware and unaware components, is one of the main causes of addiction. For this reason, we conclude that addiction is not only a medical and mental disorder, but also a social disorder.

Michele Farisco

Farisco M, Evers K and Changeux J-P (2018) Drug Addiction: From Neuroscience to Ethics. Front. Psychiatry 9:595. doi: 10.3389/fpsyt.2018.00595

International brain initiatives need cultural awareness

Pär SegerdahlToday, billions of research dollars are being invested in developing huge research collaborations about the human brain. Australia, Canada, Japan, Korea and the United States have their own brain initiatives. In Europe, the Human Brain Project has a total budget of around one billion euros over a ten-year period, 2013-2023.

Scientific research is often seen as an activity that transcends cultural differences. However, research about the brain touches such fundamental aspects of human existence that it cannot ignore cultural views. For example, the notion that the brain, as a separate organ, is the locus of human identity, of the self, is not generally embraced. Neuroscientific research touches profound cultural ideas about human life which require careful philosophical and ethical attention.

The international brain initiatives also touch other culturally sensitive issues, in addition to questions about human identity. Ideas about death and brain death, about the use of nonhuman primates in research, about privacy and autonomy, and about mental illness, differ across cultures. For example, a diagnosis that in one culture can be seen as an opportunity to get individual treatment can in another culture threaten to condemn a whole family to social isolation.

Neuroethicists from parts of the world that currently make major investments in neuroscientific research met in Korea to highlight ethical questions on cultural differences, which the international brain initiatives need to address. This in order for the research to be conducted responsibly, with awareness of relevant cultural diversity. The questions that the neuroethicists (among them, Arleen Salles) propose should be addressed are summarized in an article in the journal Neuron.

The authors mention questions about how neuroscientific research could cause stigma in individuals or social groups, and about how cultural notions might bias research design and the interpretation of results. They ask how collecting and storing neural tissue can be viewed in different cultures, and about how we should understand the moral status of robots and computer-simulated brains. They mention questions about how new brain interventions (brain devices and drugs) may affect notions of responsibility and autonomy, as well as issues about drawing boundaries between legitimate and illegitimate uses of neuroscientific techniques. Finally, questions are highlighted about fair access to research results.

How can these questions be addressed and discussed in the international brain initiatives? The authors propose education in neuroethics, as well as dialogue with scholars in the humanities and social sciences, and finally improved communication and interaction with the publics.

Within the European Human Brain Project, four percent of the budget is used for ethics and society. Similar emphasis on ethical reflection would be desirable also in other brain initiatives.

Pär Segerdahl

Global Neuroethics Summit Delegates. 2018. Neuroethics questions to guide ethical research in the international brain initiatives. Neuron 100, October 10, 2018.  https://doi.org/10.1016/j.neuron.2018.09.021

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Sharing a blog post on consciousness

Michele Farisco at CRB has written an interesting post for the BMC blog on medicine. He says that “whereas ethical analyses of disorders of consciousness traditionally focus on residual awareness, there may be a case to be made for the ethical relevance of the retained unawareness.”

Interested to read more? Here is a link to the post: On consciousness and the unconscious.

Pär Segerdahl

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