The Ethics Blog

A blog from the Centre for Research Ethics & Bioethics (CRB)

Tag: epigenetic proaction

To change the changing human

Neuron
1 June, 2021 / / 1 Comment

Neuroscience contributes to human self-understanding, but it also raises concerns that it might change humanness, for example, through new neurotechnology that affects the brain so deeply that humans no longer are truly human, or no longer experience themselves as human. Patients who are treated with deep brain stimulation, for example, can state that they feel like robots.

What ethical and legal measures could such a development justify?

Arleen Salles, neuroethicist in the Human Brain Project, argues that the question is premature, since we have not clarified our concept of humanness. The matter is complicated by the fact that there are several concepts of human nature to be concerned about. If we believe that our humanness consists of certain unique abilities that distinguish humans from animals (such as morality), then we tend to dehumanize beings who we believe lack these abilities as “animal like.” If we believe that our humanity consists in certain abilities that distinguish humans from inanimate objects (such as emotions), then we tend to dehumanize beings who we believe lack these abilities as “mechanical.” It is probably in the latter sense that the patients above state that they do not feel human but rather as robots.

After a review of basic features of central philosophical concepts of human nature, Arleen Salles’ reflections take a surprising turn. She presents a concept of humanness that is based on the neuroscientific research that one worries could change our humanness! What is truly surprising is that this concept of humanness to some extent questions the question itself. The concept emphasizes the profound changeability of the human.

What does it mean to worry that neuroscience can change human nature, if human nature is largely characterized its ability to change?

If you follow the Ethics Blog and remember a post about Kathinka Evers’ idea of a neuroscientifically motivated responsibility for human nature, you are already familiar with the dynamic concept of human nature that Arleen Salles presents. In simple terms, it can be said to be a matter of complementing human genetic evolution with an “epigenetic” selective stabilization of synapses, which every human being undergoes during upbringing. These connections between brain cells are not inherited genetically but are selected in the living brain while it interacts with its environments. Language can be assumed to belong to the human abilities that largely develop epigenetically. I have proposed a similar understanding of language in collaboration with two ape language researchers.

Do not assume that this dynamic concept of human nature presupposes that humanness is unstable. As if the slightest gust of wind could disrupt human evolution and change human nature. On the contrary, the language we develop during upbringing probably contributes to stabilizing the many human traits that develop simultaneously. Language probably supports the transmission to new generations of the human forms of life where language has its uses.

Arleen Salles’ reflections are important contributions to the neuroethical discussion about human nature, the brain and neuroscience. In order to take ethical responsibility, we need to clarify our concepts, she emphasizes. We need to consider that humanness develops in three interconnected dimensions. It is about our genetics together with the selective stabilization of synapses in living brains in continuous interaction with social-cultural-linguistic environments. All at the same time!

Arleen Salles’ reflections are published as a chapter in a new anthology, Developments in Neuroethics and Bioethics (Elsevier). I am not sure if the publication will be open access, but hopefully you can find Arleen Salles’ contribution via this link: Humanness: some neuroethical reflections.

The chapter is recommended as an innovative contribution to the understanding of human nature and the question of whether neuroscience can change humanness. The question takes a surprising turn, which suggests we all together have an ongoing responsibility for our changing humanness.

Pär Segerdahl

Written by…

Pär Segerdahl, Associate Professor at the Centre for Research Ethics & Bioethics and editor of the Ethics Blog.

Arleen Salles (2021). Humanness: some neuroethical reflections. Developments in Neuroethics and Bioethics. https://doi.org/10.1016/bs.dnb.2021.03.002

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We shape the societies that shape us: our responsibility for human nature

child's eye
5 October, 2020 / / 4 Comments

Visionary academic texts are rare – texts that shed light on how research can contribute to the perennial human issues. In an article in the philosophical journal Theoria, however, Kathinka Evers opens up a novel visionary perspective on neuroscience and tragic aspects of the human condition.

For millennia, sensitive thinkers have been concerned about human nature. Undoubtedly, we humans create prosperity and security for ourselves. However, like no other animal, we also have an unfortunate tendency to create misery for ourselves (and other life forms). The 20th century was extreme in both directions. What is the mechanism behind our peculiar, large-scale, self-injurious behavior as a species? Can it be illuminated and changed?

As I read her, Kathinka Evers asks essentially this big human question. She does so based on the current neuroscientific view of the brain, which she argues motivates a new way of understanding and approaching the mechanism of our species’ self-injurious behavior. An essential feature of the neuroscientific view is that the human brain is designed to never be fully completed. Just as we have a unique self-injurious tendency as a species, we are born with uniquely incomplete brains. These brains are under construction for decades and need good care throughout this time. They are not formed passively, but actively, by finding more or less felicitous ways of functioning in the societies to which we expose ourselves.

Since our brains shape our societies, one could say that we build the societies that build us, in a continual cycle. The brain is right in the middle of this sensitive interaction between humans and their societies. With its creative variability, the human brain makes many deterministic claims on genetics and our “innate” nature problematic. Why are we humans the way we are? Partly because we create the societies that create us as we are. For millennia, we have generated ourselves through the societies that we have built, ignorant of the hyper-interactive organ in the middle of the process. It is always behind our eyes.

Kathinka Evers’ point is that our current understanding of the brain as inherently active, dynamic and variable, gives us a new responsibility for human nature. She expresses the situation technically as follows: neuroscientific knowledge gives us a naturalistic responsibility to be epigenetically proactive. If we know that our active and variable brains support a cultural evolution beyond our genetic heritage, then we have a responsibility to influence evolution by adapting our societies to what we know about the strengths and weaknesses of our brains.

The notion of ​​a neuroscientific responsibility to design societies that shape human nature in desired ways may sound like a call for a new form of social engineering. However, Kathinka Evers develops the notion of ​​this responsibility in the context of a conscientious review of similar tendencies in our history, tendencies that have often revolved around genetics. The aim of epigenetic proaction is not to support ideologies that have already decided what a human being should be like. Rather, it is about allowing knowledge about the brain to inspire social change, where we would otherwise ignorantly risk recreating human misery. Of course, such knowledge presupposes collaboration between the natural, social and human sciences, in conjunction with free philosophical inquiry.

The article mentions juvenile violence as an example. In some countries, there is a political will to convict juvenile delinquents as if they were adults and even place them in adult prisons. Today, we know that during puberty, the brain is in a developmental crisis where important neural circuits change dramatically. Young brains in crisis need special care. However, in these cases they risk ending up in just the kind of social environments that we can predict will create more misery.

Knowledge about the brain can thus motivate social changes that reduce the peculiar self-injuring behavior of humanity, a behavior that has worried sensitive thinkers for millennia. Neuroscientific self-awareness gives us a key to the mechanism behind the behavior and a responsibility to use it.

Pär Segerdahl

Written by…

Pär Segerdahl, Associate Professor at the Centre for Research Ethics & Bioethics and editor of the Ethics Blog.

Kathinka Evers. 2020. The Culture‐Bound Brain: Epigenetic Proaction Revisited. Theoria. doi:10.1111/theo.12264

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